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Dina BELLIZZI - Professori Associati

Dina BELLIZZI

Professori Associati

Microbiologia (BIOS-15/A)


Contacts
Reception Hours

Monday 9.30-11.30

Wednesday 9.30-11.30

Dina Bellizzi is Associate Professor in Genetics at the University of Calabria. She holds a Degree in Biological Sciences, summa cum laude, and is PhD in Animal Biology. She is the author of 70 peer reviewed publications. She has collaborated in studies in model organisms and in the population in the field of genetics and epigenetics of aging. In this context, she coordinated a study aimed at correlating global DNA methylation levels with the frailty status of elderly subjects. Additionally, she contributed to demonstrate how mitochondrial DNA variants are able to modulate global DNA methylation levels. She coordinated studies demonstrating, for the first time, the methylation of cytosine residues located within the D-loop region of mitochondrial DNA and within the MT-RNR1 gene. She has collaborated on studies to investigate the epigenetic silencing of tumor suppressor genes and studied the involvement of miRNAs in the regulation of the epigenetic mechanism and their potential use as a therapy in multiple myeloma. Recently, she has published a work in which the epigenetic patterns and the relative expression levels of nuclear genes coding for factors involved in the mitochondrial quality regulation mechanism in individuals of different ages have been outlined, as well as the role of diet on global DNA methylation and on RNA methylation in rats fed specific nutritional regimes. She is currently investigating the involvement of epigenetic modifications in different cellular processes associated with antibiotic resistance in bacterial microorganisms, the antibacterial activity of natural molecules and the interactions between the gut microbiota and the host. Recently published, a series of works coordinated by her on the characterization in humans of the microbiota circulating in the blood in physiological and pathological conditions. She is the scientific referent for the authentication  of human cell lines and the determination of mycoplasma contamination services (DiBEST, Unical). She is a member of the Editorial Board of Nutrients journal and Associate Editor of Frontiers in Genetics journal.

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Dina Bellizzi is Associate Professor (BIO18-Genetics) at the University of Calabria. DB is author of 59 full papers and 70 about comunications to national and international meetings. She has carried out her scientific activity mainly in the field of Genetics and Epigenetics of Human Longevity, collaborating to studies aimed at identifying genetic factors modulating rate and quality of human aging. DB contributed to elucidate the role of the variability of the mitochondrial genome in human longevity and in modulating the expression of stress-responder nuclear genes. The research activity of DB was carried out also in the field of Systems Biology. In this frame, DB focused its activity on the modelling of the apoptosis process and on the validation of the model by experimental approaches. Recently, DB has coordinated a study aimed at correlating global DNA methylation levels with the frailty status of old subjects and contributed to demonstrate as mitochondrial DNA variants are able to modulate global DNA methylation levels. DB collaborates with different International research centers as demonstrated by the partecipation to the European research project ECHA (FP5 - European Challenge for Healthy Ageing), as responsible of DNA samples management and DNA analyses, to the European research project GEHA (FP6 - GEnetics of Healthy Aging), carrying out a role in the DNA samples management and in the mitochondrial DNA heteroplasmy analyses and to the Europen project IDEAL (FP7- Integrated research on DEvelopmental determinants of Aging and Longevity), that explored the role of early life conditions affecting late-life health, disease and aging, and the role of epigenetic regulation therein. In particular, DB coordinated studies demonstrating the presence of methylation in the mitochondrial DNA and MT-RNR1 gene.
GENERAL INFORMATION Dina Bellizzi (DB) obtained the degree in Biological Science at the University of Calabria on January 1992 (110/110 cum laude). She obtained the PhD title on Animal Biology in December 2001 at University of Calabria. On 2002 she became Assistant professor at the Department of Cell Biology, Faculty of Mathematical, Physical and Natural Science (University of Calabria). She is Associated Professor of Genetics from 1 November 2010 to 31 December 2012 at the Department of Biology, Ecology and Earth Sciences (DiBEST) of the same University. She is member of the Doctoral Committee in Life Science and Technology, TRAINING ▪ 1993-1994 Research fellowship in the frame of the project “ Genetic Engineering" - "Molecular analysis of diseases” – CNR, Rome (Italy) ▪ 1994-1995 Research fellowship in the frame of the project “Genetic Engineering” – A.BuzzatiTraverso Foundation, Pavia (Italy) ▪ 1995-1996 Research fellowship in the frame of the project “ESA RADIUS in Biotechnologies”, National Institute for the Physics of Matter (INFM) PARTICIPATION IN RESEARCH PROJECTS She collaborates with different international research centers. In this context, she participated in: i)European research project ECHA (5FP - European Challenge for Healthy Ageing, 2001-2004); ii) European research project GEHA (6FP - GEnetics of Healthy Aging, 2004-2009); iii) European research project IDEAL (Integrated research on DEvelopmental determinants of Aging and Longevity - FP7-HEALTH-2010-two stage); iv) MIUR PON Project 2007-2013(01_00937) - Experimental integrated biotechnological models for the development and selection of molecules of interest in human health; v) PRIN 2015, Discovery of molecular, and genetic/epigenetic signature underlying resistance to age-related diseases and co-morbidities, 20157ATSLF_003. She is Co-coordinator of the CRIMAC Blue- (H) ealthy: BacteriaL and virUsEs as contaminants of Emerging concern in CALabrian marine environmenTs: new tools for tHeir occurrence, distribution and dYnamics project. RESEARCH ACTIVITY She is the author of 70 full papers and 50 about communications to national and international meetings (Scopus h-index 28, citations 2698). She collaborated on studies carried out to identify genetic and epigenetic markers modulating the rateand quality of human aging. The aim of the research was to analyze candidate genes in model systems(such as rats, cybrids, and immortalized cells) as well as in population samples based on their role in biological pathways regulating aging and lifespan. She has coordinated a study aimed at correlating global DNA methylation levels with the frailty status of old subjects. In addition,she also contributedto demonstrate that mitochondrial DNA variants are able to modulate global DNA methylation levelsin humans. What is more, she has coordinated studies demonstrating, for the first time, the methylation of cytosine residues located within the D-loop region of the mitochondrial DNA and within the MT-RNR1 gene. She has collaborated on studies investigating epigenetic silencing of tumor suppressor genes. Involvement of miRNAs in the regulation of the epigenetic machinery and their potential use as therapeutics in multiple myeloma have been also investigated. Recently, she published a paper reporting the epigenetics patterns, and relative expression levels, of nuclear- encoded genes involved in mitochondrial functions in individuals of different ages as well as the roleof diet on global DNA methylation in rats fed with specific nutritional regimes. She is currently investigating the involvement of epigenetic modifications in several phenotypes of bacterial microorganisms and the crosstalk between the microbiome and the human host. In the frame of the research activity: - Scientific referent of the Cell Line Authentication service (DiBEST – UNICAL); - Member of Board for Experimental Animal Care (Organismo Preposto al Benessere Animale) (OPBA) (DiBEST-UNICAL) - Referee for several international journals, including Scientific Reports, Epigenetics, Epigenomics,Clinical Epigenetics, Journal of Cellular Physiology, Human Genetics, Trends In Genetics, Mechanism of Ageing and Development - Referee for National and International Research Projects - Referee for Doctoral Thesis. - Guest Editor of a Special Issue “Aging and Longevity between Genetic Background and Lifestyle Intervention” in BioMed Research International (2014) - Guest Editor of a Special Issue “Endocrinology of Aging” in Frontiers in Endocrinology (2019) - Guest Editor of a Special Issue "Nutrition and Epigenetics" in Nutrients (2019) - Guest Editor of a Special Issue "Effects of Dietary Interventions on DNA Methylation during Lifecycle" in Nutrients (2021) - Member of the Editorial Board of “Nutrients” journal - Review Editor of Genetics of Aging (specialty section of Frontiers in Genetics)
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Contacts
Reception Hours

Monday 9.30-11.30

Wednesday 9.30-11.30