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Daniela PELLEGRINO - Professori Associati

Daniela PELLEGRINO

Professori Associati

Fisiologia (BIOS-06/A)

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Personal information: Name: DANIELA PELLEGRINO Place/date of birth : Cerisano (CS), Italy 04/09/1967 Address: Via Valli 45, 87044 Cerisano (CS) Italy e-mail danielapellegrino@unical.it Present position: Assistant Professor of General Physiology (BIO/09), Dept. Pharmaco-Biology, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria. Education 1993 - Graduation in Biology, University of Calabria 1997 - PhD in Animal Biology, University of Calabria Research projects 1993-1996 CEE n. AIR1-CT920186 “Improvement of the nutritional value, growth and resistence to stress of eels and sturgeon by controlled dietary lipids and conditions during intensive aquaculture". University of Birmingham (Prof. E.W. Taylor), University of Copenaghen (Prof. J. Steffensen), University of Milano (Proff. L.. Bolis e Agradi), University of Napoli (Dott. C. Agnisola), University of Calabria (Prof. B. Tota). 1994-1995 CEE n. CI1-CT93-0050 “Environmental influences on the ecology and physiology of sub-antarctic fish” University of St. Andrews (Prof. I. Johnston), Marine Research Centre, Ushuaia (Dott. G. Calvo). 1996 - to date Programma Nazionale di Ricerche in Antartide (PNRA) (U.O. University of Calabria) 1998-2000 CNR 98.00.104.PF31 “Sviluppo di nuove specie e tecnologie per l’acquacoltura. Tematica 4. Biotecnologie industriali e metodologie innovative. Sottotematica 4F. Biotecnologie marine ed ambientali” University of Lecce (Prof. C. Storelli), University of Palermo (Prof. G. Zummo). 1999-2001 MURST n. 368 “Indicatori precoci di insufficienza cardiaca: applicazioni in Medicina di nuove biotecnologie; Controllo nitrergico della performance cardiaca: aspetti evolutivi” University of Napoli (Prof. O. De Divitiis). 2000-2001 Giovani Ricercatori UNICAL “Analisi biochimica dell’espressione delle isoforme costitutive (eNOS, nNOS) ed inducibile (iNOS) dell’enzima ossido nitrico sintasi nel cuore dei teleostei in condizioni fisiologiche e fisiopatologiche” University of Calabria. Scientific collaborations • Lab. of Antarctic organisms, University of Lecce. • Zoological Station “A. Dohrn”, Naples. • Lab. of Human Physiology, University of Antwerp. • Lab. of Zoology, University of Vancouver. • Institute for fiskeri-og marinbiologi HØYTEKNOLOGI-SENTERET, Bergen. • Institute for Polar and Marine Research “Alfred Wegener Human Physiology, Bremerhaven. Memberships: Physiology Italian Society Invited speaker • International Workshop: "Inotropic effects of nitrite in the vertebrate heart” award for nitrite research by Science Award Committee of NIH (National Institutes of Health of USA), Nitrite Meeting Bethesda, Maryland, 8-9 September 2005). • Physiology Italian Society, 57° National Meeting: “Cardiovascular biology of nitric oxide in Antarctic fish” (Ravenna, 25-27 September 2006). Languages Italian (first language) – English (good-speaking) Research activities: Nitric oxide role in the fish cardiovascular system Nitric oxide (NO) is an old and ubiquitous signaling molecule that mediates an unusually large repertoire of physiological effects. At cardiovascular level, NO represents one of the most important regulator of both vascular resistance and cardiac function and the principal target is soluble guanylate-cyclase with consequent release of cGMP. The aim of this research is the analysis of NO-cGMP system in the teleost heart. The research is carried out using two experimental models of teleost: Anguilla anguilla and Chionodraco hamatus (icefish). The icefishes are Antarctic teleosts and represent interesting experimental models to study NO biology. In fact, these organisms are the unique naturally-occurring “genetic knockouts”for hemoglobin, the most important mechanism for disarming NO bioactivity in vivo. This research was supported by PNRA (Programma Nazionale di Ricerche in Antartide). The biological role of nitrite in the cardiac control of vertebrate Over the last years, a growing body of evidence suggests that the nitrite anion (NO2-), present in abundance in blood and tissues, may represent the largest intravascular and tissue storage form of NO. It is well known that nitrite is converted to NO during pathological hypoxia and acidosis when NO synthase activity is inactive, but very few date are available in physiological conditions. The aim of this research is the exploration of the biological activity of nitrite as signaling molecule under basal conditions. The physio-pharmacological analysis are carried out using both mammalian (rat) and non-mammalian (Antarctic and temperate teleost) experimental models. This research is carried out in collaboration with NIH (National Institutes of Healt, Bethesda, Maryland, USA). Intracardiac localization of Nitric Oxide Sinthase isoforms The members of the nitric oxide sinthase (NOSs) family are the most regulated of known enzymes (cofactors, calcium availability, post transductional modifications, protein-protein interactions). In particular, the subcellular localisation of NOSs represents a fundamental regulatory mechanism for NO signalling. In fact, the reactive and diffusive nature of the NO signal requires that the enzymes are localised in proximity to its targets. The NOSs spatial confinement (at tissue and cellular level) is particularly critical in the heart in which NO has diverse, and sometimes opposite, influences on cardiac function. The aim of this research is the NOSs localization in the heart of both mammalian (rat) and non-mammalian (Antarctic and temperate teleost) experimental models.
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