Giuseppina ROSE
Professori Ordinari
Genetica (BIOS-14/A)
Contacts
- Dipartimento di Biologia, Ecologia e Scienze della Terra
- Dipartimento di Biologia, Ecologia e Scienze della Terra
- pinarose@unical.it
- pina.rose@unical.it
- 0984/492931
Reception Hours
Reception Hours Mondays and Wednesday from 9.30 to 11.30 (by appointment - pina.rose@unical.it)
Giuseppina Rose (GR), received her degree in Natural Sciences in April 1983 from the University of Calabria (UNICAL) and her PhD in Biochemistry and Molecular Biology from the University of Bari in 1994. Since 2020 she is Full Professor of Genetics at the Department of Biology, Ecology and Earth Sciences, University of Calabria. GR is co-author of numerous extensively published papers in international journals and communications at national and international congresses. Over the last ten years, her research interest has focused on the role of genetic variability in human ageing and longevity, and in particular on the role of mitochondrial genome variability. Her studies have led to significant contributions to the identification of genes that modulate the quality of ageing and life extension. In particular, it has contributed to elucidate the role of hereditary and somatic variability of mitochondrial DNA on the longevity phenotype. GR has recently started a line of research aimed at investigating the role of specific circulating microRNAs in the development of frailty in the elderly. GR collaborates with several international research institutions through co-participation in research networks, in national and EU-funded projects.
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Giuseppina Rose (GR) was born in Corigliano Calabro on 16th October 1958. She obtained her degree in Natural Science at the University of Calabria on April 1983.
From 1983 to 1991 she worked at the Department of Cell Biology (laboratory of Genetics) of the University of Calabria as research fellow. During this period she attended several specialized courses and was visiting research fellow at different research laboratories such as the Dept. of Chemical Pathology- King’s College School of London.
In 1992 she became Research Assistant at the Faculty of Mathematics, Physics and Natural Sciences (University of Calabria). In 1994 she had the PhD degree in Biochemistry and Molecular Biology at the University of Bari. In 2000 she became Assistant Professor of Genetics at the Department of Cell Biology of the University of Calabria. In 2003 she is Associate Professor of Genetics at the same Department. Fromm 2020 she is Full Professor of Genetics (SSD BIO/18) at the DiBEST (Department of Biology, Ecology and Earth Sciences) of University of Calabria
GR is co-author of numerous full papers on international journals and communications at national and international scientific meetings chiefly in the field of genetic variability in human populations. In the last 15 years, her research interest is focused on the role of
genetic variability in human aging and longevity, with particular attention to the mitochondrial genome. The studies in this fields gave significant contributions to the identification of genetic factors modulating rate and quality of human aging. In particular, she contributed to shed a light on the role of mtDNA variability in these complex trait. GR has recently opened a line of research aimed at investigating the role of specific circulating microRNAs in the development of frailty in the elderly.
GR collaborates with several International research institutions through the co-participation to research networks.
Personal information
Name: Giuseppina Rose
Work address: Ponte Pietro Bucci 4C, 87036 Rende (Italy)
E-mail: pina.rose@unical.it
Tel: +39 0984 492931; Fax: +39 0984 49360
Citizenship: Italian
Date of birth: 16/10/1958
Academic position: Full Professor of Genetics (SSD BIO/18) at the DiBEST (Department of Biology, Ecology and Earth Sciences) of University of Calabria
Academic and professional training
1983 - Degree in Natural Science at the University of Calabria
1985: Visiting fellow at the Dept. of Chemical Pathology- King’s College School of London (Lab of Dr. M.R. Norman)
1986-1987: Fellow at the Genetics Laboratory of the Department of Cellular Biology, University of Calabria (Scholarship established by the “Regione Calabria”)
1988: Subject expert in Genetics at the Faculty of Mathematics, Physics and Natural Sciences (S.M.F.N) - University of Calabria
1988-1989: Fellow at the Genetics Laboratory of the Department of Cellular Biology, University of Calabria (Scholarship established by the “Regione Calabria”)
1989-1990: Fellow at the Genetics Laboratory of the Department of Cellular Biology of the University of Calabria (Scholarship established by the "Associazione Scientifica Ippocrate")
1992-2000: Research Assistant at the Faculty of S.M.F.N. - University of Calabria
1994: PhD in Biochemistry and Molecular Biology at the University of Bari
2000 - 2003: Assistant Professor (SSD BIO/18-Genetics) at the Faculty of S.M.F.N. - University of Calabria
2003-2019: Associate Professor of Genetics (SSD BIO/18) at the DiBEST (Department of Biology, Ecology and Earth Sciences) of the University of Calabria
Academic activity and institutional positions
2015-present time: Member of the Research Doctorate collegium in “Life Sciences”, DiBEST - University of Calabria
2010-2014: Member of the Research Doctorate collegium in “Operational Research”, Department of Electronics, Informatics and Sistemistics (DEIS), University of Calabria
2001-2009: Member of the Research Doctorate collegium in ”Molecular Biopathology”, Department of Cell Biology, University of Calabria
2018-present: Delegate Chair of the Research Committee of the DiBEST, University of Calabria
2018- present: Member of the Steering Committee for the CdS in Biology (three-year Degree and master's Degree courses)
2017-2019: Member of the Joint Committee Teachers-Students in the DiBEST
2014-2019: Elected member of the Board of the Department of DiBEST
Scientific Activity
Giuseppin Rose (GR) started her scientific activity studying various aspect of human genetics. Her first studies concerned the analysis of genetic variability in human populations, focusing primarily on the population of the Mediterranean basin (Southern Italy, Greece, Albania). Since the second half on the nineties, she was involved in many research activities aiming at understanding the impact of genetic variability on several human complex traits, including normal and pathological aging as well as longevity.
During the last two decades, GR actively took part in many research activities in collaboration with several national and international research institutions. She is now a member of an interdisciplinary working group consisting of geriatricians, biologist, statisticians, and bioinformatics, aimed at monitoring the quality of aging in the Calabrian population. She accumulated a wide experience in the collection of cohorts of elderly subjects from Calabria and in their phenotypic characterization through the collection of clinical, metabolic, physical, and cognitive parameters, as well as in the collection of long-term follow-up data.
She exploited several analytics methods to clarify the role of genetic variability on aging and longevity, from case-control association studies by candidate gene approach, to multi-locus and genome-wide approaches, up to the integration of demographic data to genetics. The overall results obtained through these approaches, combined with longitudinal and functional studies, have made a significant contribution to the identification of genetic factors (nuclear and mitochondrial) that modulate the quality of human aging and helped to demonstrate that, in humans, inter-individual differences in aging quality and lifespan can be explained, at least in part, by polymorphic variants of genes involved in mechanisms of stress and metabolic control and nutrient utilization.
In parallel to the studies on the genetic basis of longevity, GR has carried out researches aimed at identifying genetic susceptibility factors for complex age-related diseases such as Type 2 Diabetes, Alzheimer's disease and Frontotemporal Dementia. In this context, she identified new genetic risk/protective variants involved in the development of such diseases, providing an important contribution to the understanding of the complex genetic framework underlying their pathogenesis.
In addition to genetic factors, epigenetic events are emerging as important factors in aging and longevity, with non-coding microRNAs playing an important role. In this context, GR has recently opened a line of research aimed at investigating the role of specific circulating microRNAs in the development of frailty in the elderly.
List of publications available at:
https://scholar.google.com/citations?hl=it&user=aUGVYcIAAAAJ
Participation to national and international research projects
Participant to the national project SI.F.I.PA.CRO.DE.–Sviluppo e industrializzazione farmaci innovativi per terapia molecolare personalizzata PA.CRO.DE.” PON ARS01_00568; 2021-2023
Responsible for the scientific research unit of the National Research Project (PRIN-2015) entitled “Discovery of molecular and genetic/epigenetic signatures underlying resistance to age-related diseases and comorbidities”)
Participant in the national project “PON Ricerca e Competitività 2007-2013”; Project cod. 01-00937, titled: “Modelli sperimentali biotecnologici integrati per lo sviluppo e la selezione di molecole di interesse per la salute dell’uomo”; 2011-2015).
Participant in the IDEAL project (7FP -Integrated research on Developmental determinants of Aging; 2011-2015)
Participant in the GEHA project (6FP-Genetics of Healthy Aging; 2004-2009)
Participant in the ECHA project (5FP- European Challenge for Healthy Aging; 2001-2004)
National and international collaborations
Department of Nutrition Sciences, University of Alabama at Birmingham, USA (Prof. Maria De Luca).
MRC Laboratory for Molecular Cell Biology, University College London, UK (Prof. Adolfo Saiardi).
School of Biosciences and Veterinary Medicine, University of Camerino (Prof. Valerio Napolioni)
Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche (Prof. Fabiola Olivieri).
Department of Medicine, University of Salerno (Prof. Annibale Puca).
Regional Neurogenetic Centre, ASP, CZ (Dr. Amalia Bruni).
Editorial activity
Member of the Editorial Board of the international journal Genes.
Co-Guest Editor of the special issue "Aging and Longevity between Genetic Background and Lifestyle Intervention" for the journal Biomed Research International,
Co-Guest Editor of the special issue "Genetic Determinants of Human Longevity" for the journal Genes.
Peer-reviewer for several international scientific journals including: Ageing Research Reviews, J Gerontol A Biol Sci Med Sci, Annals of Human Genetics, International Journal of Molecular Sciences, Aging Cell, Experimental Gerontology, Aging, Mechanism of aging and development.
Dissemination activities
She wrote an informative chapter on aging population entitled: “Siamo sempre più vecchi. Cause e conseguenze di un complesso fenomeni di portata globale”, all'interno del libro “Interdisciplinarità, complessità e questioni epistemiche” (Collana: Filosofia e scienza).
Since 2013 she has been actively participating in the organization of the UniStem Day, one of the most important events of scientific dissemination currently organized in Europe dedicated to high school students.
As part of the activities of the OpenLab of the University of Calabria, she held seminars in several middle and high schools.
Training activities
Supervisor of more than 60 theses of Master Degree in Biology and Health Biotechnology and more than 50 theses of Bachelor Degree in Biology and Biological Sciences and Technologies;
Supervisor for 9 PhD theses.
Tutor-teacher for students of Biology (First and Master Degree courses), of Biological Sciences and Technologies (first Degree course) and Health Biotechnologies (master Degree course)
Teaching activity (2000- present)
2021-2022: Evolutionary Genetics (4CFUs) - First Degree course in Biology (D.M. 270/04)
2009-2010-present: Human Genetics (12 CFUs) - Master Degree course in Biology (D.M. 270/04).
2016-2017-present: Cytogenetics and Prenatal Diagnosis (6 CFUs) - Master Degree course in Health Biotechnologies (D.M. 270/04).
2014-2015 - 2015/2016: Cytogenetics (4 CFUs) - Master Degree course in Biology (D.M. 270/04).
2010-2011 - 2013-2014: Cytogenetics (3 CFUs) - Master Degree course in Biology (D.M. 509/99).
2008-2009 - A.A.2009-2010: Immunogenetics (3 CFUs) - Master Degree course in Biological Sciences (D.M. 509/99).
2010-2011 - 2011-2012. Immunogenetics (4 CFUs) - Master Degree course in Biology (D.M. 270/04).
2005-2006: Eukaryotic Genetics (4 CFUs) - Master Degree course in Natural Sciences (D.M. 509/99).
2004-2005/2008-2009: Medical Genetics (4 CFUs)-Master Degree course in Biological Sciences (D.M. 509/99).
2002-2003/2008-2009: Formal and Population Genetics (5 CFUs) - First Degree course in Biological Sciences (D.M. 509/99).
2002-2003/2008-2009: Developmental Genetics (2 CFUs)- First Degree course in Biological Sciences (D.M. 509/99).
2001-2002: Laboratory Teaching in Principles of Experimental Biology (1 CFU) -First Degree course in Biological Sciences (D.M. 509/99).
2001-2002: Molecular Biology (2 CFU)-First Degree course in Biological Sciences (D.M. 509/99).
2000-2001:Biological Macromolecules (3 CFUs)-First Degree course in Biological Sciences (D.M. 509/99).
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Contacts
- Dipartimento di Biologia, Ecologia e Scienze della Terra
- Dipartimento di Biologia, Ecologia e Scienze della Terra
- pinarose@unical.it
- pina.rose@unical.it
- 0984/492931
Reception Hours
Reception Hours Mondays and Wednesday from 9.30 to 11.30 (by appointment - pina.rose@unical.it)