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Antonella LEGGIO - Professori Associati

Antonella LEGGIO

Professori Associati

Chimica organica (CHEM-05/A)

Contacts

EDUCATION

1998: PhD in Chemical Sciences at the University of Bologna

1994: Master’s degree in Chemistry at the University of Calabria

In 1991 she studied for six months at the Complutense University of Madrid Spain

PROFESSIONAL EXPERIENCE

Since November 2010 to date:  Associate Professor of Organic Chemistry at the Department of Pharmacy, Health and Nutritional Sciences of University of Calabria.

Since December 2017 to date: Coordinator of a research unit of the "NANOCAL" Project resulting from a collaboration agreement between NanoSiliCal Devices and the UNIVERSITY OF CALABRIA - Department of Pharmacy and Health and Nutrition Sciences and Department of Environmental and Land Engineering and Chemical Engineering.

Since November 2017 to date: coordinator of the research group of "Organic and Bioorganic Chemistry" at the laboratory of Organic and Biorganic Chemistry of the Department of Pharmacy and Health and Nutrition Sciences of the University of Calabria (UNICAL).

From September 2016 to February 2017: Co-responsible, as co-founder and Managing Consultant of NanoSiliCal Devices, of the European Project "NanoSil4Cancer: Smart Multifunctional silica-based Nanoparticles for Targeted Therapy", funded within the framework of the H2020 Program (Call SME instrument phase 1, TOPIC: "Supporting innovative SMEs in the healthcare biotechnology sector")

Since July 2014 to date: Co-founder and Managing consultant of NanoSilical Devices, a spin-off at the University of Calabria, Department of Pharmacy, Health and Nutritional Sciences, whose main focus is the development of mesoporous silica-based nanosystems to be exploited as a new generation of smart vehicles for targeted chemotherapy (http://www.nanosilicaldevices.com/it/).

Progetto PRIN 2007, Protocollo MIUR:2007N9A3A4_002 dal titolo: “Preparazione di sistemi multifunzionali a base di silice mesoporosa ibrida per il targeting di agenti antineoplastici ” Unità locale: Prof. Rosario Aiello, Dott. Luigi Pasqua, Dott.ssa Antonella Leggio; Coordinatore scientifico TASSONE Pierfrancesco (Università degli Studi “Magna Grecia” di Catanzaro); Altre sedi partecipanti: Università di Napoli, Università Cattolica di Roma, Università Bicocca di Milano. Ammesso al cofinanziamento

From September 2002 to October 2010: Researcher in Organic Chemistry at the Department of Pharmacy, Health and Nutritional Sciences of University of Calabria

MANAGERIAL/DEPARTMENT ROLE

Member of Quality Committee- Third Mission at the Department of Pharmacy SSN

Placement delegate

RESEARCH FIELDS

Research activity covers different organic chemistry topics, including synthetic method development of organic molecules and peptide synthesis. The activities also span drug delivery systems development and analytical organic chemistry.

The main research topics are the following:

Development of new methodologies based on the use of Lewis acids and their application to the syntheses of organic molecules of general interest.

Synthesis, both in solution and on solid supports, of peptides and peptidomimetics for use as receptor ligands, anticancer drugs or enzymatic inhibitors.

Development of new solution-phase methods for peptide synthesis

 Synthesis of modified amino acids to be used as "building blocks" for obtaining biologicaly active peptides

Design and synthesis of multifunctional hybrid Mesoporous silica-based systems for targeting and release of biologically active molecules.

Solid-phase synthesis of bioactive oligopeptides present in food products to be used for  preparing "functional foods"

Determination of organic molecules in complex matrices by Mass Spectrometry coupled to chromatographic separation techniques also by using solid phase microextraction (SPME).

TEACHING ACTIVITY

Several Organic Chemistry courses at the Department of Pharmacy, Health and Nutritional Sciences of University of Calabria.

Seminars for PhD courses and lectures by invitation for schools and research institutes and advanced training masters. He has also been supervisor of numerous experimental Degree Theses and supervisor of PhD Theses.

Since 1997-98 to date: “Chemistry of Natural Organic Substances”, “Laurea Magistrale” in Pharmacy https://www2.unical.it/portale/portaltemplates/view/view_scheda_insegnamento.cfm?66325&LANG=ITA&66325&LANG=ITA

Since 2016-17 to date: “Organic Chemistry I”, “Laurea Magistrale” in CTF https://www2.unical.it/portale/portaltemplates/view/view_scheda_insegnamento.cfm?66370&LANG=ITA&66370&LANG=ITA

2002-2003 to 2003-2004; 2014-2015 to 2015-2016; 2018-2019 to date: “Organic Chemistry”, “Laurea triennale ” in SN https://www2.unical.it/portale/portaltemplates/view/view_scheda_insegnamento.cfm?71833&LANG=ITA&71833&LANG=ITA

2013-2014: “Physical methods in organic chemistry I” “Laurea triennale” in SN

2012/2013: “Chemistry of Natural Organic Substances” “Laurea Specialistica ” in CTF

2006-2007 to 2013-2014: “Bioorganic Chemistry” “Laurea Specialistica ” in CTF

2006-2007 to 2013-2014: “Bioorganic Chemistry” “Laurea Specialistica ” in CTF

2007-2008 to 2011-2012: “Advanced Spectrometric Methodologies in Organic Chemistry I” “Laurea Specialistica ” in CTF

2005-2006 to 2006-2007: “Physical methods in organic chemistry I” “Laurea Specialistica ” in CTF

2005-2006 to 2006-2007: “Physical methods in organic chemistry II” “Laurea Specialistica ” in CTF

2002/2003 to 2003-2004: “Organic Chemistry II”, “Laurea Specialistica ” in CTF

 

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Name: Antonella First Name: Leggio Date of birth: 19.09.1967 Place of birth: Spezzano Sila (CS) - Italy Tel: +39 (0)984 492855 (Office) +39 (0)984 492078 (Laboratory) Fax: +39 (0)984 492855 E-Mail: A.leggio@unical.it Education: a.a. 1990/91: six months fellowship programme E.C.T.S. Erasmus project - University Complutense of Madrid April 22th, 1994: Degree in Chemistry, summa cum laude, University of Calabria November 1th, 1994 – October 31st, 1998: Doctorate course in Chemical Sciences, Department of Chemistry, University of Calabria May 26th, 1998: Doctorate thesis dissertation. University of Bologna Academic career: June 10th, 1991 – September 28th 1994: collaboration for research, Department of Chemistry, University of Calabria. Title of the research.” Synthesis of chiral -amino acids and chiral -ammino aldehydes ”. November 24th, 1998- October 18th 1999: one-year fellowship for research on “Characterization and measurement of halogenated organic micro-pollutants in potable waters” Consortium TEBAID, Department of Chemistry, University of Calabria. November 1,1999 – August 30 2002: four-years fellowship for the collaboration for research to the Department of Chemistry of the University of Calabria for the scientific-disciplinary sector C05X (Organic Chemistry); September 2,2002 - Agust 31,2010: researcher of Organic Chemistry (scientific-disciplinary sector CHIM/06), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria. From November 1, 2010 is associate professor of Organic Chemistry (scientific-disciplinary sector CHIM/06), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria.
Name: Antonella First Name: Leggio Date of birth: 19.09.1967 Place of birth: Spezzano Sila (CS) - Italy Tel: +39 (0)984 492855 (Office) +39 (0)984 492078 (Laboratory) Fax: +39 (0)984 492855 E-Mail: A.leggio@unical.it Education: a.a. 1990/91: six months fellowship programme E.C.T.S. Erasmus project - University Complutense of Madrid April 22th, 1994: Degree in Chemistry, summa cum laude, University of Calabria November 1th, 1994 – October 31st, 1998: Doctorate course in Chemical Sciences, Department of Chemistry, University of Calabria May 26th, 1998: Doctorate thesis dissertation. University of Bologna Academic career: June 10th, 1991 – September 28th 1994: collaboration for research, Department of Chemistry, University of Calabria. Title of the research.” Synthesis of chiral -amino acids and chiral -ammino aldehydes ”. November 24th, 1998- October 18th 1999: one-year fellowship for research on “Characterization and measurement of halogenated organic micro-pollutants in potable waters” Consortium TEBAID, Department of Chemistry, University of Calabria. November 1th, 1999 – August 30th 2002: four- years fellowship for the collaboration for research to the Department of Chemistry of the University of Calabria for the scientific-disciplinary sector C05X (Organic Chemistry); From September 2nd 2002: researcher of Organic Chemistry (scientific-disciplinary sector CHIM/06), Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Calabria. From 1 Novembre 2010: Associate Profesor of Organic Chemistry (scientific-disciplinary sector CHIM/06), Department of Pharmaceutical Didactic activity: From 1994 : “Cultore della Materia” and Member of Committee of examination for the teaching of Organic Chemistry (CHIM 06), the Faculty of Pharmacy, University of Calabria Academic year 1994/1995: Senior tutor of “Organic Chemistry”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria; “Physical Methods in Organic Chemistry”, degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. Academic year 1995/1996: Senior tutor of “Organic Chemistry”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria; “Physical Methods in Organic Chemistry”, degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. Academic year 1996/1997: Senior tutor of “Organic Chemistry”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria; “Physical Methods in Organic Chemistry”, degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. From 1997 : “Cultore della Materia” and Member of Committee of examination for the teaching of Analytical Chemistry, Faculty of Pharmacy, University of Calabria 1997: teacher in the refresher course “Methods and scientific tools for the development of the culture" for the teachers of Natural Sciences, Chemistry, Geography (Class of competition 060A) foreseen from the provincial plan of updating of the Local Education Superintendency of Cosenza, Decree n° 1086 of 23th January 1997, University of Calabria. Academic year 1997/1998: professor of “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria, Academic year 1998/1999: professor of “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria, Academic year 1999/2000: professor of “Chemistry of the Macromolecules”, degree course in Pharmaceutical Chemistry and Technologies, Faculty of Pharmacy, University of Calabria, 2000: teacher in the theoretical-practical school introducing at the Mass Spectrometry organized by the National Research Council Network of Mass Spectrometry and by the Sperimental Station for the Industries of the Essence of the by-products of citrus fruits. 10-14 April 2000 Academic year 2000/2001: professor of “Chemistry of the Macromolecules”, degree course in Pharmaceutical Chemistry and Technologies, Faculty of Pharmacy, University of Calabria, 2001: teacher in the theoretical-practical school introducing at the Mass Spectrometry organized by the National Research Council Network of Mass Spectrometry and by the Sperimental Station for the Industries of the Essence of the by-products of citrus fruits. 28 May-1 June 2001 Academic year 2001/2002: professor of “Applied Organic Chemistry”, degree course in Environmental Toxicology, Faculty of Pharmacy, University of Calabria; "Photochemistry", degree course in Environmental Toxicology, Faculty of Pharmacy, University of Calabria; Academic year 2002/2003 professor of “Applied Organic Chemistry”, degree course in Environmental Toxicology, Faculty of Pharmacy, University of Calabria; “Food Chemistry”, degree course in Nutrition Sciences, Faculty of Pharmacy, University of Calabria. "Organic Chemistry", degree course in Nutrition Sciences, Faculty of Pharmacy, University of Calabria. “Organic Chemistry II”, degree course in Pharmaceutical Chemistry and Technologies, Faculty of Pharmacy, University of Calabria; “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria. Academic year 2003/2004: professor of “Applied Organic Chemistry”, degree course in Environmental Toxicology, Faculty of Pharmacy, University of Calabria; “Organic Chemistry II”, degree course in Pharmaceutical Chemistry and Technologies, Faculty of Pharmacy, University of Calabria; "Organic Chemistry", degree course in Nutrition Sciences, Faculty of Pharmacy, University of Calabria. “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria. Academic year 2005/2006: professor of “Applied Organic Chemistry”, degree course in Environmental Toxicology, Faculty of Pharmacy, University of Calabria; “Organic Chemistry I”, degree course in Environmental Toxicology, Faculty of Pharmacy, University of Calabria; “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria. "Physical Methods in Organic Chemistry I", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. "Physical Methods in Organic Chemistry II", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. "Special synthesis and techniques in organic chemistry", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. Academic year 2006/2007: professor of “Applied Organic Chemistry”, degree course in Environmental Toxicology, Faculty of Pharmacy, University of Calabria; “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria. "Physical Methods in Organic Chemistry I", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. "Physical Methods in Organic Chemistry II", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. "Biorganic chemistry", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. Academic year 2007/2008: professor of “Applied Organic Chemistry”, degree course in Environmental Toxicology, Faculty of Pharmacy, University of Calabria; “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria. "Advanced Spectrometric Methodologies in Organic Chemistry I", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. "Biorganic chemistry", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. Academic year 2008/2009: professor of “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria. "Advanced Spectrometric Methodologies in Organic Chemistry I", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. "Biorganic chemistry", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. Academic year 2009/2010: professor of “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria. "Advanced Spectrometric Methodologies in Organic Chemistry I", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. "Biorganic chemistry", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. Academic year 2010/2011: professor of “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria. "Advanced Spectrometric Methodologies in Organic Chemistry I", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. "Biorganic chemistry", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. Academic year 2011/2012: professor of “Chemistry of Natural Organic Substances”, degree course in Pharmacy, Faculty of Pharmacy, University of Calabria. "Advanced Spectrometric Methodologies in Organic Chemistry I", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. "Biorganic chemistry", degree course in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Calabria. “Chemistry of Natural Organic Substances”, degree course in ISFPS, Faculty of Pharmacy, University of Calabria. Other scientific appointments: November 2003: member of the Organizing Committee of the Meeting “Itinerari di Chimica in Calabria 5 – La ricerca di area chimica in Calabria e le risorse del territorio”, organised by the Italian Chemical Society (SCI) – Section of Calabria, in collaboration with the University of Calabria (Rende – CS – Italy, 6-7th November 2003). October 2004: member of the Organizing Committee of the Meeting “Itinerari di Chimica in Calabria 6 – Gli sviluppi della ricerca chimica per la tecnologia e l’innovazione in Calabria”, organised by the Italian Chemical Society (SCI) – Section of Calabria, in collaboration with the University of Calabria (Rende – CS – Italy, October 21th-22th 2004). September 2007 member of the Organizing Committee of the XXXI National Organic Chemistry Congress of the Italian Chemical Society (SCI) University of Calabria, Arcavacata di Rende – CS – Italy, September 10th-14th 2007). Memberships: From 1994, member of the Italian Chemical Society (SCI), Organic Chemistry Division and Mass Spectrometry Division. Major current research interests: - Design and development of synthetic strategies for the preparation of biomolecules and their analogous with potential pharmaceutical interest; - Synthesis, Structure and Reactivity of N,O-heterocyclic compounds; - Chemistry of Organic ions in gaseous phase; -Safety of the food - Development of simple analytical procedures for the extraction by under vacuum distillation and characterization by GC/MS techniques of the volatile components of natural vegetable matrices.
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