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Vincenzo PEZZI - Professori Ordinari

Vincenzo PEZZI

Professori Ordinari

Biologia cellulare e applicata (BIOS-10/A)

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Born in Cosenza July, 18 1965 EDUCATION 1984-1989- MS Biology - Faculty of Sciences - University of Calabria (Unical) 1989-1992 - Post-graduate specialization course in Biomedical Technology - Faculty of Medicine - University of Naples ACADEMIC CAREER 1991 - 1995 Fellow Faculty of Pharmacy - Unical 1995 - 1996 Research fellow - Lab of Prof. William E. Rainey, SWT Medical Center - Dallas 1997 - 1998 Fellow Faculty of Pharmacy - Unical 1999 - 2003 Assistant Professor of General Pathology – Dep. Pharmaco-Biology - Unical 2003 - 2010 Associate Professor of Applied Biology Dep. Pharmaco-Biology - Unical 2011 - 2013 Vice-Director of the Dep. of Pharmaco-Biology, Unical 2011 - Present Full Professor of Applied Biology Dep. Pharmaco-Biology - Unical PUBLICATIONS AND BIBLIOMETRIC INDICATORS Authors of 107 papers published on International peer reviewed journals of which 2 on journal waiting for IF, 105 with IF, n. 4 chapter of book; n. 3 papers on national journals, 3 patents; 96 communication at international and national congress. Total IMPACT FACTOR: 510,817 (average IF/paper: 4,864) CITATIONS (Scopus): TOTAL CITATIONS: 4561 HI: 40. GRANTED RESEARCH PROJECTS COORDINATED AS PRINCIPAL INVESTIGATOR (PI) 2005-2008 PI of one operative unit of the project: "Effects of environmental pollutants on the process of spermatogenesis and semen quality" in collaboration with CNR, AS4 and ARPACAL, funded by EU-Calabria Region (POR 2000/2006). € 50.000. 2005-2008 PI of one operative unit of the project: "Environmental and biological monitoring of benzene exposure of police officers in Rende-Cosenza area" in collaboration with CNR, AS4 and ARPACAL, funded by EU-Calabria Region (POR 2000/2006). € 50.000. 2005-2007 PI of one operative unit of the project "Antitumor activity of polyphenol extracts from olive oil" in the project RIOM: "Research and innovation for the olive growing Southern Italy", funded by the Program of Development of the South Italy 2004 -2007. € 25.000. 2008-2009 PI of one operative unit of the project: "Effects of anabolic steroids and their functional interactions with growth factors in the development and progression of testicular tumors" funded by the Italian Ministry of Health. € 50.000. 2011-2013 PI of the project: "Integration of signaling pathways in adrenocortical carcinomas: New insights for new therapeutic approaches". Funded by AIRC (Italian Association for Research on Cancer). € 180.000. 2011-2014 PI of the operative unit Cosmetic and Pharmaceutical application of the project: Development of new technology process to use biological olive oil”. Granted by MIUR - Programma Operativo Nazionale Ricerca e Competitività 2007-2013 (PON01_00293). € 100.000. 2013-2014 PI of the project: “Estrogen Receptors as innovative target for the treatment of Adrenocortical Carcinoma” granted by European Union - Programma Operativo Regionale Calabria FSE 2007-2013. € 75.000. 2014-2016 PI of the project: "Selective estrogen receptor modulators (SERMs): a new tool for targeted therapy in adrenocortical cancer". Funded by AIRC (Italian Association for Research on Cancer) in collaboration with Prof. William E. Rainey University of Michigan in Ann Arbor. € 195.000. 2018-2022 PI of the project: “Estrogen Related Receptor α (ERRα) a key metabolic factor as target to prevent Adrenocortical Cancer progression” Funded by AIRC (Italian Association for Research on Cancer) in collaboration with Prof. Lisanti’s lab, at the University of Manchester, UK, € 414.000. SCIENTIFIC COLLABORATION AND TRAINING ABROAD 1995-1996 Research fellow - Lab of Prof. William E. Rainey and Prof. Bruce Carr Department of Obstetrics and Gynecology - Division of Reproductive Endocrinology - UTSW Medical Center - Dallas – Texas 1996 Visiting research scientist (November) Lab of Prof. Serge Carreau Dep. Biochimie-IRBA UPRES EA 2608 Université de Caen (France). 1998-1999 Collaboration with Lab of Prof. D'Armiento University "la Sapienza"of Rome and with Lab of Prof. Andò Unical for the project granted (PRIN 1998): "Molecular effects of thyroid hormone on gonads". 1999 Visiting research scientist (January) - Lab of Prof. Sassone-Corsi - Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) CNRS - INSERM - Université Louis Pasteur - Strasburg (France). 2000 Visiting research scientist (May) Lab of Prof. Rainey, Department of Obstetrics and Gynecology - Division of Reproductive Endocrinology – UT SW Medical Center - Dallas - Texas. 2001 Visiting research scientist (February) Lab of Prof. Mathis del Department of Cellular Biology and Anatomy- Lousiana State University Medical Center at Shreveport (Lousiana). 2001 Visiting research scientist (September - October) Labs of Profs. Rainey and Carr - Department of Obstetrics and Gynecology - Division of Reproductive Endocrinology – UT SW Medical Center - Dallas - Texas. Short-term mobility fund granted by C.N.R. 2001-2002 Collaboration with Lab of Prof. D'Armiento, University "La Sapienza" Rome and with Lab of Prof. Andò Sebastiano Unical for the project granted (PRIN 2001): Mechanisms of regulation of aromatase expression in testis and in testicular tumor cell lines. From 2003 Collaboration with Labs of Dr. Clyne and Prof Simpson - Prince Henry’s Institute of Medical Research - Clayton-Melbourne (Australia), on projects investigating molecular mechanisms regulating aromatase gene expression in several tissues. 2004-2005 Collaboration with Lab of Prof. Andò Unical for the project granted (PRIN 2004): " Role of aromatase expression in testicular tumoro-genesis”. From 2008 Collaboration with Lab of Prof. Carreau, Research Director of CNRS, Chairman unit EA 2608-USC 2006 INRA Dep. Biochimie-IRBA Université de Caen (France) on a project investigating the role of new estrogen receptor GPR30 (GPER) in rat testis. From 2010 Member of European Network ENS@T (European Network for the Study of Adrenal Tumors) 2012-2016 Member of the Operational Unit coordinated by Prof. Francesco Fallo of the project entitled: “Study of molecular markers for the diagnosis and prognosis and the development of new therapeutic strategies for cancer of the adrenal gland. National Project Coordinator: Prof. Massimo Mannelli (University of Firenze), other Member: Prof. Vincenzo Toscano (University of Rome “La Sapienza”) funded by "FIRB AGREEMENT PROGRAM 2011". From 2014 Collaboration with lab of Prof. Lisanti - Breakthrough Breast Cancer Research Unit and the Manchester Centre for Cellular Metabolism, Institute of Cancer Sciences, University of Manchester, UK. 2015 Visiting Professor (October) Department of Molecular & Integrative Physiology and Internal Medicine Endocrine Neoplasia Basic Research Unit -University of Michigan in Ann Arbor. Invited speaker in many national and international congress SOCIETY Member of The Endocrine Society; Italian Association of Biology and Genetics (AIBG); Italian Society of Toxicology of Reproduction; Italian Society of Andrology and Medicine of Sexuality; Member of European Network ENS@T (European Network for the Study of Adrenal Tumors). EDITORIAL BOARD AND PEER REVIEW Associated Editor for: Frontiers in Endocrinology Associated Editor for: International Journal of Molecular Sciences Editorial Board for: ISRN Endocrinology Ad hoc Reviewer for several international journals of endocrinology, cancer and cell biology. EXPERTISE Prof. Pezzi was Research Fellow in the Prof. Rainey’s Lab (1995-1996), in Dallas and during that period, he worked on molecular mechanisms regulating the expression of enzymes involved in steroidogenesis, contributing to clarify the pathways involved in these processes. The collaboration with Prof. Rainey's Lab in this field is still ongoing and has yielded the publication of 12 full papers. In 1999 he became assistant Professor of General Pathology at the University of Calabria and from that period on his main research interest has focused on molecular mechanisms regulating the expression of aromatase and the role of estrogen signaling in several normal and tumor tissues, such as testis, breast, ovary and adrenal. Some of these studies were carried on in collaboration with prestigious and international research labs (Prof. Evan Simpson and Dr. Colin Clyne - PHIMR, Monash Medical Center Clayton, Australia; Prof. Serge Carreau Dep. Biochimie-IRBA Université de Caen -France; Prof. Andò and Prof. Maggiolini from University of Calabria. From 2001 to 2005 Prof. Pezzi carried out his research as a participant in two granted “PRIN projects” - PI Prof. S. Andò – University of Calabria: "Mechanisms of regulation of aromatase expression in testis and in testicular tumor cell lines " (PRIN 2001) and “Role of aromatase expression in testicular tumoro-genesis” (PRIN 2004). Prof. Pezzi has publishing 14 full papers contributing to clarify the role of estrogen signaling in spermatogenesis and Leydig cell tumor. Moreover, he has contributed to characterize the activity of the novel membrane estrogen receptor, GPER, in several cellular types producing 8 full papers as co-author. In particular, his studies have shown a direct involvement of ERs and GPER in mouse spermatogonia, spermatocytes and spermatids in regulating proliferation and apoptosis along spermatogenesis. From 2014 he started a collaboration with Prof. Lisanti’s lab, at the University of Manchester, UK, aimed to investigate the role of Estrogen receptors and Estrogen-related receptors in regulating mitochondrial metabolism and the metabolic shift from Glycolysis and OXPHOS in endocrine tumors such as adrenocortical cancer. In the last 8 years, on these topics Prof. Pezzi has been recipient of two grants funded by AIRC.
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