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Loredana MAURO - Professori Associati

Loredana MAURO

Professori Associati

Patologia generale (MEDS-02/A)

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Dr. Loredana Mauro Senior Assistant Professor of General Pathology Department of Cellular Biology Laboratory of Endocrine Physiopathology University of Calabria Personal data • Birth: 26/01/1967 • Birth Place: Cosenza • Work Address: Department of Cellular Biology University of Calabria, 87030 Rende (CS) Italy • Home Address: Via Sabotino, 13 – 87100 Cosenza (CS) Italy • Phone: +39.0984.492928 • Fax: +39.0984.492929 • E-mail: maurol@unical.it doclollo@yahoo.com Education 1994 Graduate in Biological Science at the University of Calabria 1996-1999 Ph.D. in Animal Biology, Department of Cellular Biology, University of Calabria. Research and Professional Experience 1992-1994 Internship. Department of Cellular Biology, University of Calabria. 1995-96 A Fellowship granted by Regione Calabria at the Department of Cellular Biology, University of Calabria. 2000-2002 Contract for research, Department of Pharmaco-Biology, University of Calabria 2002-2005 Assistant Professor of General Pathology (MED/04), Department of Cellular Biology, University of Calabria. 2003-present Member of Ph.D. in Cellular Biochemistry and Drugs Activity in Oncology, University of Calabria 2005-present Senior Assistant Professor of General Pathology (MED/04), Department of Cellular Biology, University of Calabria. 2006-present Member of Post-Graduate School of Clinical Pathology. University of Calabria. 2013-present Member of the College of Teachers and tutors of the PhD in “Translational Medicine”, at the Department of Pharmacy and Health Sciences and Nutrition, University of Calabria. Additional information 1998-1999 Research fellow at the Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA, USA Didactic career 2002/2003 - Professor of General Pathology to Biological Science students - Professor of Endocrinology to Biological Science students 2003/2004 - Professor of General Pathology to Biological Science students - Professor of Hormonal Methodologies to Biological Science students 2005/2006 - Professor of Molecular Pathology to Biological Science students - Professor of Hormonal Methodologies to Biological Science students - Professor of Molecular Endocrinology to Biological Science students - Professor of Genetic Pathology to Pharmacy students 2006/2007 - Professor of Molecular Pathology to Biological Science students - Professor of Molecular Endocrinology to Biological Science students - Professor of Genetic Pathology Applied to Pharmacy students - Professor of Cellular and Ultracellular Pathology to Post-Graduate School of Clinical Pathology students 2007/2008 - Professor of Molecular Pathology to Biological Science students - Professor of Molecular Endocrinology to Biological Science students - Professor of Molecular Pathology to Scientific Drug Information students - Professor of Cellular and Ultracellular Pathology to Post-Graduate School of Clinical Pathology students 2008/2009 - Professor of Molecular Pathology to Biological Science students - Professor of Molecular Endocrinology to Biological Science students - Professor of Molecular Pathology to Scientific Drug Information students - Professor of Cellular and Ultracellular Pathology to Post-Graduate School of Clinical Pathology students 2009/2010 - Professor of Molecular Pathology to Biological Science students - Professor of Molecular Endocrinology to Biological Science students - Professor of Molecular Pathology to Scientific Drug Information students - Professor of Cellular and Ultracellular Pathology to Post-Graduate School of Clinical Pathology students 2010/2011 - Professor of Molecular and Ultrastructural Pathology to Biological Science students - Professor of Molecular Pathology to Scientific Drug Information students -Professor of Molecular Pathology II to Post-Graduate School of Clinical Pathology students 2011/2012 - Professor of Molecular and Ultrastructural Pathology to Biological Science students - Professor of Molecular Pathology II to Post-Graduate School of Clinical Pathology students 2012/2013 - Professor of Molecular and Ultrastructural Pathology to Biological Science students - Professor of Molecular Pathology II to Post-Graduate School of Clinical Pathology students 2013/2014 - Professor of Molecular and Ultrastructural Pathology to Biological Science students - Professor of Molecular Pathology II to Post-Graduate School of Clinical Pathology students Research Projects Participate in the following founded research projects: P.O.P. Calabria 1994/99 misura 4.4: “Molecular basis of hormone-dependency of human mammary tumor: effects of new antiestrogenic molecules on the functional interaction beetwen nuclear and membrane receptors”. P.R.I.N. 1998: “Differentiative and molecular effects of thyroid hormone at genital level” C.N.R. programma Biotecnologie (legge 95/95) 1999/2001: “New approach of bimolecular study of mechanisms of action of anti-tumoral drugs (antiestrogens) in hormone-dependent human breast cancer cell lines” A.I.R.C. 2001/2003: “Role of interaction between ERalpha and IRS-1 signaling on cell adhesion and invasiveness in breast cancer”. A.I.R.C. 2005/2006: “Molecular mechanisms involved in leptin-induced cell growth and progression in breast cancer”. A.I.R.C. 2007/2009: “PPAR gamma ligands as antagonists of ER alpha/E2 signalling in breast cancer: in vitro and in vivo effects”. My First AIRC Grant 2008/2010: “Role of adipocytokines in breast cancer hormone-resistance. An approach to identify new therapeutical targets”. P.R.I.N. 2008: “Functional role exerted by the new membrane estrogen receptor GPR30 in hormone-sensitive tumors”. 2007-2013. Pon Ricerca e Competitività - Asse I – “Experimental models of biotechnological approaches to the development and selection of molecules of interest to human health”. Code: PON01_00937. A.I.R.C. 2011/2014 “FXR ligands as novel agents able to inhibit breast tumor growth and progression” Research interests Dr. Mauro is author of many papers published as refereed full papers. The research interest has addressed the endocrine oncology, and specifically the molecular mechanism underlying the functional interaction through ERalpha and IGF-I transductional pathway in human breast cancer. Recently, the research interest has been focused on the role of leptin, a hormone secreted by adipocytes, in amplifying estrogen signaling in human breast cancer. From this study it emerges how leptin may play an important role in development and progression of human breast cancer, particularly in obese postmenopausal women. These data strengthen furthermore how leptin signaling may represent a target of novel pharmacological tools to be exploited in the new therapeutical adjuvant strategies for breast cancer treatment. Professional Societies - Union Internationale Contre le Cancer (U.I.C.C.) - Italian Society of Pathology (SIP) - American Society for Investigative Pathology (ASIP) Reviewer of the following scientific journal - Cell Death & Differentiation Technical skills - Cell Culture - Monolayer, three-dimensional cultures and mammospheres - Cell lines used: MCF-7, MCF-10, MDA-MB-231, MDA-MB-468, BT20, HeLa, SK-BR-3, BG-1, Ishikawa, CHO - MTT assay - [3H]Thymidine Incorporation - Transient and stable transfection - DNA, RNA and Protein extraction - Western blot and Immunoprecipitation analysis - Northern blotting - EMSA (Electrophoresis Mobility Shift Assay) - Chromatin Immuno Precipitation assay (ChIP) - PCR and RT-PCR - Site-Directed Mutagenesis - Immunofluorescence - Immunocytochemistry - Soft agar assay - Wound healing assay - Pulse chase labelling - Bacterial Transformation - In vivo models
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