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Tommaso ANGELONE - Professori Ordinari

Tommaso ANGELONE

Professori Ordinari

Fisiologia (BIOS-06/A)

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Reception Hours

Monday: 9.00 - 11.00

Friday: 9.00 - 11.00

Present position: Full Professor of Physiology at University of Calabria(UNICAL). PhD in Animal Biology (Cardiovascular Physiology) at University of Calabria (UNICAL) and in Molecular and Cellular Aspects of Biology at INSERM575- University Louis Pasteur (Strasbourg, France). Scientific director of the Lab. of Cellular and Molecular Cardiovascular Patho-Physiology-UNICAL. Teaching in Neurophysiology and Applied physiology and in Human Nutrition-UNICAL. Membership: Scientific Board of Doctorate Fellowship in Life Sciences, UNICAL, Scientific Board of Italian Society for Cardiovascular Research (SIRC) and National Institute of Cardiovascular Research (INRC), member of Italian Physiological Society. Recent Projects Partecipation: from 2016 Coordinator of Galileo Project for Italy-France collaboration; from 2014 Director of Thesis for Vinci Project for Italy-France collaboration; from 2011 to 2014 PON 01_00937: “Modelli sperimentali Biotecnologici integrati per lo sviluppo e la selezione di molecole di interesse per la salute dell’uomo”. From 2011 to 2015 PON01_00293: “Spread Bio Oil: valutazione dell’impatto nella dieta e suscettibilità all’infarto del miocardio”. Awards.2015: “SIRC”.2013: “SIRC”; 2012: “Italian Society of Physiology; 2010 and 2011:“Società Italiana per le Ricerche Cardiovascolari”;2005: “Istituto Italiano per le Ricerche Cardiovascolari”;2003:“Consorzio Interuniversitario per la Ricerca Cardiovascolare”. Collaborations: Dr. Anouar, University of Rouen (France); Prof. Corti (San Raffaele Institute, Milan); Dr. Loh (NIH-Bethesda-USA); Prof.Mahata, University of San Diego,USA; Dr. Metz-Boutigue (INSERM, France); Proff. Pagliaro, Alloatti (Univerity of Turin). Prof.Angelone was Guest Editor of a several Special Volume and of a Book on Springer (2016/2017) and is reviewer for several International Journals (ISI). Prof.Angelone is Section Editor for Journal of Translational Medicine, Section: Cardiovascular, Metabolic and Lipoprotein Translation and Associate Editor for:1)Frontiers in Physiology: Section Vascular Physiology, 2)Frontiers in Physiology: Section Cellular Neurophysiology, 3)Antioxidants, 4)Journal of Clinical Medicine, 5)Plos One. Prof.Angelone published 111 full papers (ISI Journals).

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Full Professor of Physiology at University of Calabria(UNICAL). PhD in Animal Biology (Cardiovascular Physiology) at University of Calabria (UNICAL) and in Molecular and Cellular Aspects of Biology at INSERM575- University Louis Pasteur (Strasbourg, France). Scientific director of the Lab. of Cellular and Molecular Cardiovascular Patho-Physiology-UNICAL. Teaching in Neurophysiology and Applied physiology and in Human Nutrition-UNICAL. Membership: Scientific Board of Doctorate Fellowship in Life Sciences, UNICAL, Scientific Board of Italian Society for Cardiovascular Research (SIRC) and National Institute of Cardiovascular Research (INRC), member of Italian Physiological Society. Recent Projects Partecipation: from 2016 Coordinator of Galileo Project for Italy-France collaboration; from 2014 Director of Thesis for Vinci Project for Italy-France collaboration; from 2011 to 2014 PON 01_00937: “Modelli sperimentali Biotecnologici integrati per lo sviluppo e la selezione di molecole di interesse per la salute dell’uomo”. From 2011 to 2015 PON01_00293: “Spread Bio Oil: valutazione dell’impatto nella dieta e suscettibilità all’infarto del miocardio”. Awards.2015: “SIRC”.2013: “SIRC”; 2012: “Italian Society of Physiology; 2010 and 2011:“Società Italiana per le Ricerche Cardiovascolari”;2005: “Istituto Italiano per le Ricerche Cardiovascolari”;2003:“Consorzio Interuniversitario per la Ricerca Cardiovascolare”. Collaborations: Dr. Anouar, University of Rouen (France); Prof. Corti (San Raffaele Institute, Milan); Dr. Loh (NIH-Bethesda-USA); Prof.Mahata, University of San Diego,USA; Dr. Metz-Boutigue (INSERM, France); Proff. Pagliaro, Penna (Univerity of Turin). Prof.Angelone published 111 full papers.
TOMMASO ANGELONE birth date: 09/07/1976 birth place: Rogliano (CS), Italy Tel: 0984492902/2904 Fax: 0984492906 E-Mail: tommaso.angelone@unical.it Curriculum Studiorum •2017: National Scientific Qualification to Full Professor in Physiology (SSD BIO/09) •2014: Associate Professor (SSD BIO/09) in Physiology, University of Calabria, Cosenza-Italy •2008: Researcher (SSD BIO/09) in Physiology at the Faculty of Science, University of Calabria, Cosenza-Italy •2005: European PhD in “Molecular and Cellular Aspects of Biology” at INSERM575 Physiopathology of Nervous System, University Louis Pasteur-Strasbourg, France and in “Animal Biology” (Cardiovascular Physiology) at University of Calabria – Cosenza (Italy •2001: Doctor Degree in Pharmaceutic Chemistry and Technology at the Faculty of Pharmacy, University of Calabria (UNICAL), Cosenza (Italy) Academic Career • Present position: Full Professor (SSD BIOS-06/A; ex BIO/09; Physiology) at Dept. Biology, E. and E.S. (DiBEST), University of Calabria, Cosenza-Italy Scientific National and International Commitments • Since 2020: President of the Italian Society of Cardiovascular Research (SIRC) • Since 2010: Member of Scientific Board of National Institute of Cardiovascular Research (BO), Italy University Functions • Since 2020: Coordinator of the Doctorate Fellowship in Life Sciences and Technology- UNICAL • 2017-2021: Member of the “Presidio di Qualità (PQA)” for teaching and research – UNICAL • Since 2014: President of the Board for Experimental Animal Care (“Organismo Preposto al Benessere Animale”) (DiBEST-UNICAL) Since 2007: Scientific director of the Cellular and Molecular Cardiovascular Patho-Physiology Lab (DiBEST-UNICAL), Operative Unit of the National Institute of Cardiovascular Research (INRC). Research Group: -Dr. Carmine Rocca, PhD, Researcher (RTDb) -Dr. Anna De Bartolo, Researcher (RTDa) -Dr. Maria Concetta Granieri, Post-doc -Dr. Alessandro Marrone, Post-doc -Dr. Naomi Romeo, PhD student -Dr. Marika De Cicco, PhD student International Patents 1) International Patent Pub. No.: WO/2019/068682 International application No.: PCT/EP2018/076735 Publication Date: 11/04/2019 International Filing Date: 02/10/2018 Priority Data: 17306319.9 03/10/2017 EP Title: Selenoprotein T 43-52 as cardioprotector Section: Methods and pharmaceutical composition for providing cardioprotection in subjects who experienced a myocardial infarction Inventors: Tommaso ANGELONE, Youssef ANOUAR, Carmine ROCCA & Loubna BOUKHZAR 2) International Patent Pub. No.: WO2020070089 International Application No. PCT/EP2019/076507 Publication Date: 09/04/2020 International Filing Date: 01/10/2019 Priority Data: 01/10/18 Title: Chromogranin A and uses thereof Inventors: Tommaso ANGELONE, Bruno TOTA & Angelo CORTI Referee and Editor Activities Section Editor for: 1) Journal of Translational Medicine, Section: Cardiovascular, Metabolic and Lipoprotein Translation Associate Editor for: 1) Frontiers in Physiology: Section Vascular Physiology 2) Frontiers in Physiology: Section Cellular Neurophysiology 3) Antioxidants Review Editor for: 1) Frontiers in Physiology: Section Cardiovascular Biologics and Regenerative Medicine 2) Frontiers in Physiology: Section Cellular Biochemistry 3) Frontiers in Physiology: Section Redox Physiology Editorial activity: • Lead Editor of the Special issue “Oxidative and Nitrosative Stress in Vascular Diseases: The Heart/Brain Connection”. Oxidative Medicine and Cellular Longevity. • Co-Guest Editor of the Special Issue “The vascular frontiers: Updates from the XXIII Italian Congress of Cardiovascular Research” on Vascular Pharmacology. • Co-Guest Editor of the Special Issue “Oxidative/Nitrosative Stress-Related Mechanisms and Antioxidant Therapy in Cardiovascular Diseases”. Antioxidants. • Co-Editor of the Special Volume “Chromogranin A and its Derived Peptides in Health and Disease”. Current Medicinal Chemistry 2012, 19, 24. • Editor of the volume “Chromogranins: from Cell Biology to Physiology and Biomedicine”. Unipa Springer Series (Springer Verlag) 2017. • Co-Editor for Current Medicinal Chemistry for the Special Issue “Mechanisms, and pathophysiology of obesity: upgrading a complex scenario”. 2018. -Reviewer for several International Journal (ISI), such as: Reviewer for VQR 2011-2014, Journal of Cellular Physiology, Journal of American Heart Association, Redox Biology, Frontiers in Physiology, Frontiers in Cellular Neuroscience, Translational Research, Oncotarget, Journal of Molecular & Cellular Cardiology, Journal of Molecular & Cellular Medicine, Plos One, Nutrition, Metabolism and Cardiovascular Diseases, Journal of Nutritional Biochemistry, Journal of Cellular Biochemistry, Journal Pharmacological Experimental Therapeutics, Current Medicinal Chemistry, Biomarkers in Medicine, Nutrition Research, Metabolism, Pharmacological Research, Biomedicine & Pharmacotherapy -Reviewer for National and International research Projects -Referee for national and international Doctoral Thesis. - Tutor for PhD students of Doctorate in Life Sciences and Technology, for postdoctoral positions and supervisor of several research fellowship at University of Calabria. Main Research Interest Research: Neurohumoral control of the cardiac performance of mammals with focus on the activity, cardioprotection after ischemia/reperfusion injury and the signal transduction pathway of: i) chromogranin-A and its derived peptides; ii) selenoprotein T and a synthetic derived peptide encompassing the redox active motif; iii) nitric oxide and nitrite; iii) adrenergic stimulation; iv) heart and nutrition; v) cardiomodulation and cardioprotection elicited by hormones involved in the alimentary behaviour (e.g. glucagon-like peptide 2, nesfatin-1, phoenixin) e by food-derived natural substances (e.g. red wine polyphenols, olive-oil extracts). Researches are carried out by using innovative methods of physiological investigation at organ and cellular and molecular levels, such as the perfusion of organs by a digitalized Langendorff apparatus, cultures of cardiomyocytes and endothelial cells, molecular biology techniques such as western blotting, immunoprecipitation, PCR, ELISA, Biotin Switch, receptor binding assay, Immunocytochemistry analysis, HPLC and Mass Spectrometry. Experimental models: rats and mice fed with different high fat diets able to induce obesity and metabolic syndrome; spontaneously hypertensive rats (SHR), spontaneously hypertensive rats prone to heart failure (SHHF), rats with heart failure (chronically treated with heart failure stimulators, such as isoproterenol) rats and mice with chemotherapy-induced cardiotoxicity (treated with doxorubicin). Prof. Angelone’s research is focused on the endocrine/paracrine/autocrine mechanisms which contribute to regulate cardiac performance at cellular, tissue and organ level, with particular regard to the role of nitric oxide and of peptides and proteins cited above as well as their transduction mechanisms. Results have enlarged the knowledge on the circuits which sustain cardiac homeostasis under normal condition and in the presence of physio-pathologic stress, with notable biomedical relevance. In particular, Prof. Angelone’s research described the cardioactivity elicited by Chromogranin-A (CGA)-derived peptides. Moreover, Prof. Angelone observed that this protein precursor is present in the human hypertrophic and dilated ventricular myocardium, where it co-localizes with BNP. Moreover, he found that, at cardiac level, this protein is cleaved into bioactive fragments. These peptides protect the myocardium like ischemic pre and post-conditioning. Since in chronic heart failure circulating CgA increases depending on the severity of the disease, also being an independent prognostic indicator of mortality, results on CgA fragments are of notable basic and biomedical-clinical interest. Projects • Since 2023: Partecipation to the Research Program POS 4 CAL.HUB.RIA, Responsible for "Physiolgy" study [Obiettivo Specifico 2 (OS2)_AT3]. • Since 2022: Partecipation to the Research Program PNRR-AGE-IT (“Heart Aging”), Responsible for "Physiolgy" study. • Since 2022:Partecipation to the Research Program TECH 4 YOU, Responsible for "Physiolgy" study. •Since 2021: Partecipation to the Research Program “PNR 2015-2020, PON, Area di Specializzazione: Salute”. • Since 2019: Coordinator of the Research Project: “Proof of Concept”, Ministero dell'istruzione, dell'università e della ricerca di cui al D.D. n. 467 del 02.03.2018, Area: Salute. Project code: POC01_00049 • Since 2019: Coordinator of the Research Program “Progetto Vinci” (as Director of Thesis) for co-tutorship with the INSERM U1239 on Selenoprotein T and metabolism. • 2019: Responsible of the Research Program for Post-doctoral fellowship “Ruolo della Cromogranina-A nell'insufficienza cardiaca”, Fondazione Umberto Veronesi, Milano • 2017: Participation to the Research Program POR ASSE I –n° J88C17000370006. • 2016: Coordinator of the Research Project within the Italian-French cooperation “Progetto Galileo” (Prot.71/2016 n°G16-2) with University of Rouen (Francia), Inserm U982 that includes a co-tutorship doctorate program. • 2016: Partecipation to the Research Program PON: “HEARTDRIVE: Servizi avanzati per una più efficace ed efficiente gestione clinica integrata dello Scompenso Cardiaco e delle sue principali comorbilità”. • From 2011 to 2015: Partecipation to the Research Program PON01_00937: “Modelli sperimentali Biotecnologici integrati per lo sviluppo e la selezione di molecole di interesse per la salute dell’uomo” • From 2011 to 2016: Partecipation to the Research Program PON01_00293: “Sviluppo di nuovi processi tecnologici per la produzione di emulsioni innovative a base d’olio d’oliva biologico a consistenza controllata (Spread Bio-oil)” • From 2014 to 2017: Partecipation to the Research Program “Progetto Vinci” (as Director of Thesis) for co-tutorship with the INSERM U1121, Biomatériaux et Bioingéniér, Strasbourg (France). • From 2014 to 2016: Coordinator of the Research Program “PROGRAMMA DI INTERVENTO PO CALABRIA FSE 2007/2013 – ASSE IV – OBIETTIVO OPERATIVO M2 ASSEGNI DI RICERCA UNIONE EUROPEA “ARUE” that includes an Italian-USA cooperation (Prof. SK Mahata, University of California, San Diego USA). Collaborations Prof. Angelone research is carried out in collaboration with many national and international laboratories. Researches on CgA and its derived peptides are carried out in collaboration with San Raffaele Institute (DIBIT, Milan, Prof. A. Corti), with Dep. of Medicine and Molecular Genetic Center (Univ. California, San Diego: Prof. S. Mahata), Cell Neurobiology Section (NIH, USA: Dr. P. Loh), Institute for Nervous System Physiopathology INSERM (Strasbourg, France: Prof. M.-H. Metz-Boutigue). Researches on Selenoprotein T are carried out in collaboration with the Unit of “Différenciation et Communication Neuronale et Neuroendocrine-Institut de Recherche et d'Innovation Biomédicale (IRIB)” Inserm U1239 (Univ. Rouen Normandy: Dr. Y. Anouar). Researches on ischemic cardioprotection are carried out in collaboration with sono Dept. Of Clinical and Biological Sciences (Univ. Turin, Italy: Prof. P. Pagliaro and Prof. C. Penna) e with Dept. Of Life Sciences and System Biology (Univ. Turin: Prof. G. Alloatti and Prof. M.P. Gallo). Research on the estrogen receptor GPER in the heart is in collaboration with Dept. of Pharmacy (Univ. of Calabria, Italy) Prof. M. Maggiolini. Meetings Participation: Since 2003: participation to several National and International Meetings (oral/poster presentation and Invited speaker) Meetings Organization: 2022: President of the Scientific Board for VI Workshop “New Roads in Cardiovascular Research”, to be held in Bari on July 1, 2022. 2021: President of the Scientific Board for XXIII Congresso Nazionale della Società Italiana di Ricerche Cardiovascolari, Imola, 27-30 October 2020: President of the Scientific Board for V Workshop “New Roads in Cardiovascular Research”, “La ricerca cardiovascolare ai tempi del COVID-19”, Forum on line, 16 October 2019: Member of the Scientific Board for XXII Congresso Nazionale della Società Italiana di Ricerche Cardiovascolari, Imola, 6-8 November 2018: Member of the Scientific Board for IV Workshop “New Roads in Cardiovascular Research”, Rome 6 October 2017: Member of the Scientific Board for XXI Congresso Nazionale della Società Italiana di Ricerche Cardiovascolari, Imola, 16-18 November 2016: Member of the Scientific Board for III Workshop “New Roads in Cardiovascular Research”, Genova, 18 June 2015: Member of the Scientific Board for XX Congresso Nazionale della Società Italiana di Ricerche Cardiovascolari” Imola, 26-28 November 2014: Member of the Scientific Board for II Workshop “New Roads in Cardiovascular Research”, Pisa, 13 October 2013: Member of the Scientific Board for XIX Congresso Nazionale della Società Italiana di Ricerche Cardiovascolari” Imola, 17-18 October 2012: Member of the Scientific Board for I Workshop “New Roads in Cardiovascular Research”, Milan, 23-24 November2011: Member of the Scientific Board for XVIII Congresso Nazionale della Società Italiana di Ricerche Cardiovascolari” Imola, 21-22 October2011: Organization, in collaboration with Prof. Tota, of the 7th International Meeting on Chromogranin A and it derived-peptides” Capri (Naples, Italy) April 26-28 Publications Since 2003: Prof. Angelone published 134 (ISI Web of Knowledge) research products, of which 111 full papers (ISI Journals). total Impact Factor (IF): 521.8 (average IF/paper) 5.7 total citations (Scopus): 3452 (Google Scholar): 4772 H index: 35 (Scopus)_ (Google Scholar): 41, i10-index: 94 -5 of these full papers received an Editorial [Angelone et al., 2008 Endocrinology; Angelone et al., 2008 Acta Physiologica; Pieroni et al., 2007 European Heart Journal; Rocca et al., 2018 Acta Physiologica (Oxf); Rocca et al., 2020 Acta Physiologica (Oxf)]. -2 Book Chapters -~ 200 Proceedings and Meeting Participations Relevant publications - Lionetti V, Bollini S, Coppini R, Gerbino A, Ghigo A, Iaccarino G, Madonna R, Mangiacapra F, Miragoli M, Moccia F, Munaron L,Pagliaro P, Parenti A, Pasqua T, Penna C, Quaini F, Rocca C, Samaja M, Sartiani L, Soda T, Tocchetti CG, Angelone T. Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development. Pharmacol Res. 2021 Jun;168:105581. doi: 10.1016/j.phrs.2021.105581. IF 7.658, Q1 - Moccia F, Gerbino A, Lionetti V, Miragoli M, Munaron LM, Pagliaro P, Pasqua T, Penna C, Rocca C, Samaja M, Angelone T. COVID- 19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.Geroscience 2020;20:1-29. IF 7.713, Q1 - Rocca C, Grande F, Granieri MC, Colombo B, De Bartolo A, Giordano F, Rago V, Amodio N, Tota B, Cerra MC, Rizzuti B, Corti A,Angelone T * & Pasqua T *. The chromogranin A1-373 fragment reveals how a single change in the protein sequence exerts strong cardioregulatory effects by engaging neuropilin Acta Physiol (Oxf) 2020 Oct 18;e13570. IF 6.311, Q1 *equally contributed - Angelone T, Rocca C, Pasqua T. Nesfatin-1 in cardiovascular orchestration: From bench to bedside. Pharmacol Res 2020;156:104766. IF 7.658, Q1 -Rocca C, PasquaT, Cerra MC, Angelone T. Cardiac Damage in Anthracyclines Therapy: Focus on Oxidative Stress and Inflammation. Antioxid Redox Signal. 2020;20;32(15):1081-1097. IF 8.401, Q1 - Angelone T, Filice E, Pasqua T, Amodio N, Galluccio M, Montesanti G, Quintieri AM, Cerra MC. Nesfatin-1 as a novel cardiac peptide:identification, functional characterization, and protection against ischemia/reperfusion injury. Cell Mol Life Sci. 2013 Feb;70(3):495-509. doi: 10.1007/s00018-012-1138-7. IF 9.261, Q1 - Rocca C, Pasqua T, Boukhzar L, Anouar Y, Angelone T. Progress in the emerging role of selenoproteins in cardiovascular disease:focus on endoplasmic reticulum-resident selenoproteins. Cell Mol Life Sci. 2019 Jun 19. doi: 10.1007/s00018-019-03195-1. IF 9.261,Q1 - Rocca C, Scavello F, Colombo B, Gasparri .....Pasqua T, Cerra MC, Tota B, Corti A, Angelone T. Physiological levels of chromogranin A prevent doxorubicin-induced cardiotoxicity without impairing its anticancer activity. FASEB J. 2019 Jun;33(6):7734-7747. doi: 10.1096/fj.201802707R. IF 5.191, Q1 - Rocca C, Boukhzar L, Granieri MC, Alsharif I, .... Leprince J, Cerra MC, Anouar Y, Angelone T. A selenoprotein T-derived peptide protects the heart against ischaemia/reperfusion injury through inhibition of apoptosis and oxidative stress. Acta Physiol (Oxf). 2018 Aug;223(4):e13067. doi: 10.1111/apha.13067 IF 6.311, Q1 - Rocca C, Scavello F, Granieri MC, Pasqua T, ...Mazza R, Cerra MC, Angelone T. Phoenixin-14: detection and novel physiological implications in cardiac modulation and cardioprotection. Cell Mol Life Sci. 2018 Feb;75(4):743-756. doi: 10.1007/s00018-017-2661-3. IF 9.261, Q1 - Penna C, Pasqua T, Perrelli MG, Pagliaro P, Cerra MC, Angelone T. Postconditioning with glucagon like peptide-2 reduces ischemia/reperfusion injury in isolated rat hearts: role of survival kinases and mitochondrial KATP channels. Basic Res Cardiol. 2012 Jul;107(4):272. doi: 10.1007/s00395-012-0272-6. IF 17.165, Q1 -Pieroni M, Corti A, Tota B, Curnis F, Angelone T, Colombo B, Cerra MC, Bellocci F, Crea F, Maseri A. Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function. Eur Heart J. 2007 May;28(9):1117-27. doi: 10.1093/eurheartj/ehm022. IF 29.983, Q1 - Cerra MC, De Iuri L, Angelone T, Corti A, Tota B. Recombinant N-terminal fragments of chromogranin-A modulate cardiac function of the Langendorff-perfused rat heart. Basic Res Cardiol. 2006 Jan;101(1):43-52. doi: 10.1007/s00395-005-0547-2 IF 17.165, Q1.
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Reception Hours

Monday: 9.00 - 11.00

Friday: 9.00 - 11.00