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Giuseppe PASSARINO - Professori Ordinari

Giuseppe PASSARINO

Professori Ordinari

Genetica (BIOS-14/A)

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Giuseppe Passarino was born in Cosenza on 1964. He graduated at the University of Calabria in 1988. At present he is Full Professor of Genetics, President of the graduation programs in Biology and in Biotechnologies, and member of the board of trustees at the University of Calabria. His research activity started at the University of Pavia, in the field of the variability of mitochondrial DNA and Y chomosome. This research was continued in Leiden University, in 1993-1994. In 1994 he becomes Assistant Professor at the Department of Cell Biology of the University of Calabria. In 1999 he is Research Associate at the Medical School of Stanford University(California), where he studies the evolutionary history of Homo sapiens. In 2002 he is Associate Professor of Genetics at the Department of Cell Biology of the University of Calabria. From February 2007 he is Full Professor of Genetics at the same Department. At present his interest is focused on the role of genetic variability in aging and longevity. He has been involved in different national and international projects. Since 2004 he is the coordinator of a group of work including geriatricians, biologists, statisticians and bioinformatics which is monitoring the quality of aging of the Calabrian elderly population and is searching for biological and non biological basis of the aging- related functional decline. He has been coordinator of the recruitment of ultra nonagenarian sib pairs within the European Project GEnetics of Healthy Ageing (GEHA, 6th FP) and coordinator the GEHA work group on mitochondrial DNA. From February 2011 he is partner of a new European Project focused on epigenetic of longevity (IDEAL, 7th FP). He has published about 100 full papers on international journals and is ranked among Top Italian Scientists (http://www.topitalianscientists.org). GP is member of the editorial board of the journals "Biogerontology" and "Frontiers in Aging genetics".
Giuseppe Passarino Curriculum Vitae Present and main past positions Giuseppe Passarino is Full Professor of Genetics at the University of Calabria (since 2007), where he is also Director of the Laboratory of Genetics, and Head of the Department of Biology, Ecology and Earth Sciences. He is also director of the "OpenLab for the dissemination of scientific culture". GP is member of the Scientific Committee of the Italian National Recearch Center on Ageing (INRCA)and of the Valter Longo foundation. In the past, he has been, as Full Professor of the University of Calabria, member of the management board (2009-2013), Responsible for Research and Technological Transfer (2015-2019), coordinator of the Graduation Program in Biology and in Biological and Biotechnological Sciences (2011-2019), Coordinator of the Ph.D. in Molecular Biopathology (2009-2010). Previously, he was Post Doc at the Department of Human Genetics at the University of Leiden (The Netherlands)(1993-1994), Assistant professor at the University of Calabria(from 1994-1999), Research associate at the School of Medicine of the Stanford University (1999-2001), Associate professor of Genetics at the University of Calabria(2002-2007). Moreover, GP has been member of the steering committee of the Italian Association of Geneticists (in the periods 2013-2015 and 2017-2019)and member of the National Governing Board of PNIcube (the Italian association of University Incubators). Summary of editorial activity GP has co-authored more than 200 papers on international journals (https://pubmed.ncbi.nlm.nih.gov/?term=passarino+g&sort=date&size=100), such as Nature Genetics, Science, American Journal of Human Genetics, PNAS. His publications granted GP to be ranked among "Top Italian Scientists" (http://www.topitalianscientists.org). He is member of the editorial board of the journals "Ageing Research Reviews", “Biogerontology”, “Geriatrics”, "Experimental Gerontology", “Mechanisms of Ageing and Development”, “Frontiers in Genetics of Aging”. Of note, with respect to the present project, in 2019 he was guest editor of the issue "Nutrition and Epigenetics" for the journal "Nutrients" (https://www.mdpi.com/journal/nutrients/special_issues/Nutrients_Epigenetics).GP Is also member of the editorial board of the Book Series "Phylosophy and Science", edited by the Italian Publisher "Aracne". On March 2022, on Google Scholar (https://scholar.google.co.uk/citations?user=OlDpiogAAAAJ&hl=en) he can boast more than 15000 citations and an H-index of 57. H-index on Scopus is 49 with more than 10000 citations, while on ISI it H-index is 47 with more than 7000. Summary of the research activity The research activity of GP started at the department of Genetics and Microbiology of the University of Pavia, where- after the graduation- he worked as research fellow in the field of the variability of mitochondrial DNA and of Y chomosome in human populations. This research, was then continued in the Laboratories of the Leiden University, where he spent about two years , 1993-1994, as post doc. In 1994 he became Assistant Professor at the Department of Cell Biology of the University of Calabria, where he focused on the variability of mitochondrial variability in East African and Asian populations. In 1999 he is Research Associate at the Medical School of the Stanford University (California), where he took part to the reappraisal of the evolutionary history of Homo sapiens sapiens through the analysis of Y Chromosome and mitochondrial DNA. In 2002 he is Associate Professor of Genetics at the Department of Cell Biology of the University of Calabria. From February 2007 he is Full Professor of Genetics at the same Department. Since 2004 he is the coordinator of a group of work including geriatricians, biologists, statisticians and bioinformatics which is monitoring the quality of aging of the Calabrian elderly population and is searching for biological and non biological basis of the aging- related functional decline. In this field he contributed to shed a light on the different hereditability of the longevity trait in different population and on the effects this phenomenon has on the males/female ratio among centenarians; in addition, he has participated to studies aimed at defining, by means of innovative statistic demographic approaches, longevity phenotypes and quality-of-aging phenotypes which have allowed to analyze the influence of genetic variability on these traits. Finally, he has contributed, also by means of multilocus approach, to the identification of genetic loci affecting, with their variability, human aging an longevity. Since 2012 GP has focused on the epigenetics of ageing, contributing to the definition of epigenetic clocks, to the discovery of epigenetic biomarkers of frailty, to the analysis of the correlation between epigenetic markers and nutrition. Of note, the research group of GP was the first to characterize the methylation of mitochondrial DNA and to characterize a mitochondrial epigentic marker (the methylation of mitochondrial nt 931)which is correlated to the survival chance. Summary of the funded research programs Giuseppe Passarino has been involved for many years in different national and international projects for the study of human aging and longevity. He has been member of the coordination of the European Challenge for Healthy Ageing Project (ECHA, 5th Framework Program), Then he was member of the board for the coordination of the recruitment of ultra nonagenarian sib pairs within the European Project GEnetics of Healthy Ageing (GEHA, 6th Framework Program) and coordinator the GEHA work group on mitochondrial DNA. From February 2011 to February 2016 he was partner of the European Project "Integrated Research on Developmental determinants of AGeing and Longevity" (IDEAL, 7th Framework Program), focused on epigenetics of ageing and longevity and which included 14 labs from different European countries. He has been national coordinator of program “The influence of mitochondrial DNA variability on mitochondrial and cellular functionality and its consequence on human ageing” funded by Italian Ministry of Education and Research (MIUR) in 2004-2006. In 2009-2011 he was Responsible of one of the partner units of the program “Role of Epigenetics and mitochondrial DNA Genetics on Longevity: a study on subjects over 105 years of age” (funded by MIUR). From January 2017 he is Coordinator of the Program “Advanced Technology for the analysis of the relationship between human beings and environmental facors” funded by Private investors to monitor the factors contributing to the wellbeing in Calabria (Southern Italy) and to study the molecular and epigenetic markers to describe it.
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