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Francesca AIELLO - Professori Associati

Francesca AIELLO

Professori Associati

Chimica farmaceutica (CHEM-07/A)

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Reception Hours

Daily by appointment

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Dr Francesca Aiello is an Assistant Professor SSD CHIM08 Department of Pharmacy and Health and Nutrition Sciences University of Calabria- 87036- Rende francesca.aiello@unical. Fraduated in Pharmaceutical Chemistry and Technology at the University of Siena in 1998 and 1999 she obtained the qualification to Pharmacist. From 1999 to 2004 she benefited from three scholarships and a two-year research grant, related to the SSD CHIM 08. From October 2004 until August 2005 she was Visiting Scholar in the laboratory of Prof. Nouri Neamati at the Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA . Since 2006 she is Assistant Professor for the CHIM / 08 PHARMACEUTICAL CHEMISTRY sector. MAIN RESEARCH LINES - synthesis of selective ligands of GPCRs and TRPVs; - The design and synthesis of small molecules with anticancer activity; - The search for new synthesis methods for obtaining aromatic heterocyclic compounds; - Extraction and semi-synthesis of structural analogues of molecules of natural origin, with antioxidant, anti-inflammatory and analgesic activity. _ Functional Foods.- TRPV1 ligands N° FI2014A000096. Brizzi Antonella,Aiello Francesca,Corelli Federico, UNISI UNICAL -Preparato per uso topico a base di 2-(3,4-diidrossifenil) -5,7-diidrossi-4-oxo-4H-cromen-3-il oleato, in associazione con acido ialuronico per l’uso nel trattamento di ulcere e ferite cutanee Brevetto per invenzione industriale N. 102017000111372, TITOLARE/I:CIONE ERIKA AIELLO FRANCESCA, GALLELLI LUCA PROJECTS WP1 Scientific Coordinator: regional project (POR) named GlasOil (CUP J77H18000280006), funded to design and formulate a new Olive Oil-based dressing.
Francesca Aiello, PhD Assistant Professor in Medicinal Chemistry Department of Pharmacy, Health and Nutritional Sciences Department of Excellence MIUR 2018-2020 University of Calabria- Rende-Italy Email: francesca.aiello@unical.it | Telephone: +39 0984 493154 PERSONAL STATEMENT. Assistant Professor with high experience in the Organic Synthesis inspired to green chemistry and innovative/eco-friendly methods of extraction of natural compounds from agri-chemical and foods wastes, interesting for new therapeutics and functional foods preparations. Graduated in 1998 with a degree in Toxicological and Pharmaceutical Chemistry, possess Advanced Chromatographic techniques (GCMS) spectroscopic magnetic resonance (1H and 13 C NMR), and infra-red (FTIR) skills. The preferred targets are TRPVs and GPCR’s and their involvement in Type 2 Diabetes, Obesity, Pain, and Wound healing. Investigation of new natural and synthetic molecules endowing cardiovascular activities. Author of 88 Documents (Article70, Review12, Book Chapter4), among these the 75% belonging to first quartile (Q1); 1412 Citations by 1084 documents, 19 h-index. The Most contributed Topics 2016–2020 are: Grape Pomace; Antioxidant; Vitis 5 documents; Fasiglifam; Agonist; Nonesterified Fatty Acids 4 documents; Quercetin; Flavanols; Flavonoid 2 documents. The research activity falls in the fields of Medicinal Chemistry and mainly in the Biochemistry, Genetics and Molecular Biology (58 papers), Pharmacology, Toxicology and Pharmaceutics (55 papers), Chemistry (40 papers), Agricultural and Biological Sciences (12 papers). KEY ACHIEVEMENTS and AWARDS. In 2021 she won a Best Paper Award for the article Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway (doi: 10.3390/antiox8060186). In 2020 due to the novelty of the molecules synthesized and published in Discovery of 1,4-Naphtoquinones as a New Class of Antiproliferative Agents Targeting GPR55, ACS Medicinal Chemistry Letters, 2019,10,402-406, she gets recognition by CAS REGISTRY INNOVATOR. She is CEO of the Start-Up QLB Health Sciences S.r.l.s and in 2018 she received the recognition Best Technology Start-Ups established by concession of the President of the Italian Republic, at the Foundation COTEC for the category University and Public Research. In the 2017 she won the Clinic Center Life Sciences Award participating in the PNI 2017 with an innovative idea named RyGoldZip. EMPLOYMENT HISTORY 03/2006 – Present- Assistant Professor (permanent employment) University of Calabria ● Extraction of natural compounds by green methods; ● Chemical characterization (NMR; GC-MS, FT-IR); ● Design and synthesis of new hybrid molecules active towards innovative and attracting therapeutic targets and functional foods. 10/2004 – 08/2005 Department of Pharmaceutical Sciences, School of Pharmacy University of Southern California, Los Angeles, CA Postdoctoral Research Fellow-Visiting Scholar 01/2002 – 05/2004 University of Calabria, Italy Recipient of a grant for a research project on the Synthesis of Selective Inhibitors of HIV-1 Integrase 01/2001 – 31/2001 University of Calabria, Italy Lecturer, Quantitative Analytical Medicinal Chemistry. 01/2000 – 31/2000University of Siena, Italy Recipient of a grant for a research project on Design and Synthesis of New D3-receptor ligands. 12/1998 – 12/1999University of Salerno, Italy2000 Recipient of a grant for a research project on New Anticancer Chemotherapeutics. CAREER ADVANCEMENT OF YOUNG ACADEMICS • Number of supervised completed Masters-Theses: >70; • Number of supervised completed PhD-Theses: 3 (Translational Medicine). SUPERVISION OF GRADUATION IN PROGRESS • Number of Masters-Theses: 5. PROJECTS Scientific Coordinator of WP1 WP1 Scientific Coordinator: regional project (POR) named GlasOil (CUP J77H18000280006), funded to design and formulate a new Olive Oil-based dressing. Member of the research team for the project “SI.F.I.PA.CRO.DE. - Sviluppo e industrializzazione farmaci innovativi per terapia molecolare personalizzata PA. CRO. DE.” PON area di specializzazione “Salute”, ARS01_00568 (2021 – in progress). PATENTS: - TRPV1 ligands N° FI2014A000096. Brizzi Antonella,Aiello Francesca,Corelli Federico, UNISI UNICAL -Preparato per uso topico a base di 2-(3,4-diidrossifenil) -5,7-diidrossi-4-oxo-4H-cromen-3-il oleato, in associazione con acido ialuronico per l’uso nel trattamento di ulcere e ferite cutanee Brevetto per invenzione industriale N. 102017000111372, TITOLARE/I:CIONE ERIKA AIELLO FRANCESCA, GALLELLI LUCA COLLABORATIONS Nouri Neamati, Ph.D. John G. Searle Professor of Medicinal Chemistry Translational Oncology Program Department of Medicinal Chemistry College of Pharmacy, University Prof. Anna Maria Aloisi, Department of Medicine, Surgery and Neuroscience, University Dr Vincenzo Di Marzo e Dr Luciano De Petrocellis Endocannabinoid Research Group, Consiglio Nazionale delle Ricerche, Pozzuoli, Napoli. Dr. Margarita Vega Holm, presso il Dipartimento di QUÍMICA ORGÁNICA Y FARMACÉUTICA Universidad de Sevilla, Dr. James D. Adams, ASSOCIATE PROFESSOR, DEPARTMENT OF PHARMACOLOGY & PHARMACEUTICAL SCIENCES USC Los Angeles California
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Contacts
Reception Hours

Daily by appointment